(4-acetamidocyclohexyl) nitrate
(4-acetamidocyclohexyl) nitrate
CAS: 137213-91-3
Molecular Formula: C8H14N2O4
(4-acetamidocyclohexyl) nitrate - Names and Identifiers
| Name | (4-acetamidocyclohexyl) nitrate |
| Synonyms | 137213-91-3 (4-acetamidocyclohexyl) nitrate Acetamide, N-[trans-4-(nitrooxy)cyclohexyl]- |
| CAS | 137213-91-3 |
(4-acetamidocyclohexyl) nitrate - Physico-chemical Properties
| Molecular Formula | C8H14N2O4 |
| Molar Mass | 202.21 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Boling Point | 378.8±22.0 °C(Predicted) |
| pKa | 15.48±0.40(Predicted) |
| In vivo study | The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively. |
(4-acetamidocyclohexyl) nitrate - References
| biological activity | (4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase. |
Last Update：2024-04-09 21:04:16
